There are also differences in terms of the mechanism of action of a drug? Of course, depending on t

The pediatric field, with regard to the medical alkaline profession, alkaline is one of the most troubled and difficult alkaline to treat for several reasons: first, patients are subject recognized as "weak" at the international level since there are still individuals who have obtained a full development in terms of physical, alkaline mental and therefore require special attention that the State, in accordance with the International Convention on the Rights of the Child, must necessarily give (I refer to the original document for further study http://www1.interno.gov.it/mininterno/site/it/sezioni/servizi/legislazione/minori/La_Convenzione_sui_diritti_dellxinfanzia_.html ); in the second place, the concept of the disease alkaline is already difficult per se to be addressed by an adult person, as can be questioned all projects that the subject was predetermined to obtain: an adult with a chronic disease, for example will have to change his lifestyle and his work as a result of this event; So we can imagine how it is for a child, which sometimes can not understand the severity and the inability to do the same things as his peers, and his family, who feels guilty party without any reasons and partly concerned about the fate of his son.
The doctor then has to load these huge responsibilities, as well as the disease that affects the small patient. It is not always easy. One of the problems with which the physician often has to make concerns the proper management of drug therapy because, both physically and metabolism, pharmacokinetics alkaline varies greatly from one child, one adult and one senior. In recent months, the LAV has posted on his Facebook page and on its website this.
In these comments alkaline one can sense that, since there are differences between adults alkaline and children, necessarily there are differences alkaline even between animals and humans, and then test a drug on an animal before moving to the clinical stage is useless alkaline or misleading.
Too bad this "free" interpretation of this initiative does not take into account some aspects: the campaign AIFA talk about clinical trials and non-clinical; therefore, from the results of this in vitro and animal models, we want to promote a better conduction of clinical trials on patients in order to increase our understanding of these molecules and dosages to use, trying to improve their effectiveness ; it is therefore, in the vast majority of cases, trials aimed to study the location of these active ingredients within our body (a concept that is called pharmacokinetics) and to create a case study justifies an indication on the package leaflet of a drug ; This campaign also aims to reduce the cases of off-label use of the drug, ie outside of its indications for which it was approved by the national regulatory authorities, as well as discourage the use of the drug in the wrong mode by doctors and parents. alkaline
The discussion then on the mechanism of action (ie, pharmacodynamics) is not minimally addressed by this campaign; on the other hand would be quite bizarre, just as an example, assume that a given antibiotic against a microorganism does not work just because it is used by an adult or a child; the same way, if you want to quote the speech on side effects, just remember that these are in most related to dose-dependent effects (thus connectable to what medication is assumed) and which, for this reason, in 70% of cases may be predictable and potentially preventable by the physician and medical staff.
So why is there this difference between adult and child? Many of the differences that doctors observed between these two populations are related to different pharmacokinetics of a drug; for example the body of a child contains a larger amount of liquid than the lipids, as a factor that influences drug is distributed in the body.
Factors such as this and others can influence, even heavily, on the response to drugs that we observe in the child answer alkaline in itself difficult to assess in some cases or technical limitations related to the child, such as the respiratory response in asthma therapy alkaline .
There are also differences in terms of the mechanism of action of a drug? Of course, depending on the age and degree of maturity can have different answers, and the fact that some diseases have a history and a different evolution, related to immaturity of certain processes, such as the liver in the early days life. But for this reason it is necessary to have a series alkaline on children, just to be able to collect much data as possible and leave behind a past of